
The majority of cases worldwide in 2012 were in the South-East Asia (29%), African (27%) and Western Pacific (19%) regions. In 2013, an estimated 9.0 million people developed TB and 1.5 million died from the disease, 360 000 of whom were HIV-positive. Tuberculosis (TB) remains one of the world’s deadliest communicable diseases. "Immunomodulator Potential of Miana Leaves( Coleus s cutellar i oides (L) Benth) in Prevention of Tuberculosis Infection." American Journal of Microbiological Research 3, no.

Pakadang, Sesilia Rante, Chatarina Umbul Wahjuni, Hari Basuki Notobroto, Dwi Winarni, Ressy Dwiyanti, Yadi, Muhammad Sabir, and Mochammad Hatta.American Journal of Microbiological Research, 3(4), 129-134. Immunomodulator Potential of Miana Leaves( Coleus s cutellar i oides (L) Benth) in Prevention of Tuberculosis Infection. "Immunomodulator Potential of Miana Leaves( Coleus s cutellar i oides (L) Benth) in Prevention of Tuberculosis Infection." American Journal of Microbiological Research 3.4 (2015): 129-134. American Journal of Microbiological Research. Sesilia Rante Pakadang, Chatarina Umbul Wahjuni, Hari Basuki Notobroto, Dwi Winarni, Ressy Dwiyanti, Yadi, Muhammad Sabir, Mochammad Hatta.tuberculosis colony in infected wistar lung. Conclusion, Miana leaves extract (Coleus scutellarioides, (L) Benth.) increased the number of T-lymphocytes, CD4 T-cell counts, levels of IFN-γ and TNF-α and decreased in the number of M.

tuberculosis colonies after EDM treatment. Result, Results showed the increasing of T-lymphocytes, CD4 T-Cells, the levels of IFN-γ, TNF-α and decreasing in the number of M. tuberculosis colonies derived from the rat lung in LJ media.

In this study we measure the level of Immunomodulatory parameter the number of T-lymphocytes and CD4 T-cells measured by flowcytometry method, the levels of IFN-γ and TNF-α were measured by ELISA and the number of M. tuberculosis H37Rv strain and subsequently given a placebo, EDM and GAB (combined Rifampicin and EDM) and healthy control animals were treated with EDM. Aim, The aim of this study to investigate the immunonomodulator effects of miana leaves ( Coleus s cutellar i oides (L) Benth) on prevention of tuberculosis in wistar rats, Method, Samples of white male Wistar rats were divided into 4 groups, the samples were treated with miana leaves extract (EDM) and then infected by intra tracheal M.
